Peptide discovery services refer to the professional services provided to clients for the discovery and design of peptide drugs. These services are typically offered by biotechnology companies, drug development organizations or specialized peptide discovery companies.
Main components of peptide discovery services
Include the following
1. Peptide library screening: Peptide discovery typically involves screening candidate molecules with desired biological activity from peptide libraries. Peptide libraries can be natural peptide libraries, synthetic peptide libraries, or virtual peptide libraries. Screening methods can include high-throughput screening, bioactivity screening or computer-aided screening.
2. Peptide design: Based on known biological activity or structural information of target proteins, peptide design can be achieved through computer simulation, molecular docking and structure optimization to design peptides with desired activity. Peptide design can be targeted towards specific drug targets or disease areas.
3. Peptide synthesis: Peptide discovery services usually also include the synthesis and purification of peptides. Peptides can be synthesized using solid-phase synthesis, liquid-phase synthesis or a combination of methods. Peptide purification is done to obtain high-purity peptide samples for subsequent bioactivity evaluation and drug development work.
4. Bioactivity evaluation: Discovered peptide candidates need to undergo bioactivity evaluation to determine their affinity, selectivity and function towards target proteins. Bioactivity evaluation can include in vitro experiments, cell experiments and animal model experiments.
5. Optimization and improvement: Based on the results of bioactivity evaluation, discovering peptide candidates may need structural optimization and improvement to enhance their activity, stability, and drug-like properties. This can be achieved through the synthesis of peptide derivatives, modifications or post-translational modifications.
The goal of peptide discovery services is to provide clients with peptide candidates with potential drug activity and support for subsequent drug development. These services can accelerate the discovery and development process of peptide drugs and provide professional technical support and expertise.
